Deneysel Hipertansiyon Oluşturulan Sıçanlarda Rosuvastatinin Böbrek Üzerine Koruyucu Etkileri

Hypertension is responsible for approximately 30% of patients who reach end-stage renal disease. Caspase-3 an important protein in the apoptosis tubular epithelial cells. The presence fibrillin-1(FBN1) microfibrils structure kidney glomerulus causes changes FBN1 levels hypertensive kidney. Statin therapy known to reduce risk developing In this study, caspase-3 and tissue rats with hypertension using N-Nitro-L-Arginine Methyl Ester (L-NAME) were investigated along how rosuvastatin affected caused by on these proteins.
 To induce hypertension, given L-NAME 7 weeks. After second week, was oral gavage 5 Blood pressure values evaluated days 0, 14, 28, 42. At end experiment, all sacrificed evaluated.
 pressures found be higher group 14th, 28th, 42nd (p